Chemical and Toxicological Analyses of Lake Calumet (Cook County, Illinois) Sediments

HWRIC Project 88-048NTIS PB90-16072

Biological and toxicological investigations of Chicago area navigation projects

unpublishednot peer reviewe

Summary of Toxicological Data for Aquatic Organisms of Illinois

The data presented in this report contain Information on toxicity testing performed on organisms that could be found In aquatic habitats in Illinois. To compile this information a thorough list of all aquatic organisms in Illinois was required. This was constructed through literature searches and personal communication with scientists who collect and identify Illinois aquatic specimens. Each species name was used to search a database which contained toxicity information on aquatic organisms. No toxicological Information was found for many Illinois species. For most organisms, all available information retrieved from the database is presented. For species on which extensive toxicological research has been performed, data showing 96 hour LC50 or EC50 values and chronic testing values constitute the bulk of the records. In addition to records detailing toxicity values and experimental conditions, a list of tested chemical compounds and organisms is included. Literature citing observations and identification of aquatic organisms within Illinois was the most valuable resource in compiling a list of Illinois aquatic species. Staff of the Illinois Natural History Survey were helpful in recommending the most useful publications, making available their own field lists, and helping to update taxonomy and nomenclature from older reports. In particular we would like to acknowledge Don Webb, Larry Page, Warren Brigham, Mark Wetzel, Kevin Cummings, and Allison Brigham from the INHS Faunistics section and Michael Henebry from the section of Aquatic Biology. To retrieve toxicity data on the aquatic organisms of Illinois, a Chemical Information System, Inc. database, AQUIRE (Aquatic Information Retrieval System), was employed. AQUIRE contains data extracted from publications dealing with the toxic effects of chemical substances on aquatic organisms. Each Latin species name from the compiled Illinois list was used to search records in the database. If AQUIRE matched a record with the species name, the record was stored. If there were an excessive number of matching records, the search was narrowed by specifying particular regimens and/or effective endpoint types. Ultimately a printout of the records pertaining to each organism was produced. The data contained In this report are duplications of the AQUIRE records obtained for Illinois organisms. The taxonomy, habitat, and Illinois distribution is listed immediately preceding the AQUIRE records compiled for each species. These records have been substantially reduced from their original size and are arranged by chemical compound in alphabetical and/or numerical order.published or submitted for publicationis peer reviewe

A systematic review of compositional data analysis studies examining associations between sleep, sedentary behaviour, and physical activity with health outcomes in adults

This systematic review determined if the composition of time spent in movement behaviours (i.e., sleep, sedentary behaviour (SED), light physical activity, and moderate-to-vigorous physical activity (MVPA)) is associated with health in adults. Five electronic databases were searched in August 2019. Studies were eligible for inclusion if they were peer-reviewed, examined community-dwelling adults, and used compositional data analysis to examine the associations between the composition of time spent in movement behaviours and health outcomes. Eight studies (7 cross-sectional, 1 prospective cohort) of >12 000 unique participants were included. Findings indicated that the 24-h movement behaviour composition was associated with all-cause mortality (1 of 1 analyses), adiposity (4 of 4 analyses), and cardiometabolic biomarkers (8 of 15 analyses). Reallocating time into MVPA from other movement behaviours was associated with favourable changes to most health outcomes and taking time out of SED and reallocating it into other movement behaviours was associated with favourable changes to all-cause mortality. The quality of evidence was very low for all health outcomes. In conclusion, these findings support the notion that the composition of movement across the entire 24-h day matters, and that recommendations for sleep, SED, and physical activity should be combined into a single public health guideline. (PROSPERO registration no.: CRD42019121641.) Novelty The 24-h movement behaviour composition is associated with a variety of health outcomes. Reallocating time into MVPA is favourably associated with health. Reallocating time out of SED is associated with favourable changes to mortality risk

The 2020 Westmorland, California Earthquake Swarm as Aftershocks of a Slow Slip Event Sustained by Fluid Flow

Swarms are bursts of earthquakes without an obvious mainshock. Some have been observed to be associated with transient aseismic fault slip, while others are thought to be related to fluids. However, the association is rarely quantitative due to insufficient data quality. We use high-quality GPS/GNSS, InSAR, and relocated seismicity to study a swarm of >2,000 earthquakes which occurred between 30 September and 6 October 2020, near Westmorland, California. Using 5 min sampled Global Positioning System (GPS) supplemented with InSAR, we document a spontaneous shallow Mw 5.2 slow slip event that preceded the swarm by 2–15 hr. The earthquakes in the early phase were predominantly non-interacting and driven primarily by the slow slip event resulting in a nonlinear expansion. A stress-driven model based on the rate-and-state friction successfully explains the overall spatial and temporal evolution of earthquakes, including the time lag between the onset of the slow slip event and the swarm. Later, a distinct back front and a square root of time expansion of clustered seismicity on en-echelon fault structures suggest that fluids helped sustain the swarm. Static stress triggering analysis using Coulomb stress and statistics of interevent times suggest that 45%–65% of seismicity was driven by the slow slip event, 10%–35% by inter-earthquake interactions, and 10%–30% by fluids. Our model also provides constraints on the friction parameter and the pore pressure and suggests that this swarm behaved like an aftershock sequence but with the mainshock replaced by the slow slip event

Delphi-Consensus Weights for Ischemic and Bleeding Events to Be Included in a Composite Outcome for RCTs in Thrombosis Prevention

To weight ischemic and bleeding events according to their severity to be used in a composite outcome in RCTs in the field of thrombosis prevention.Using a Delphi consensus method, a panel of anaesthesiology and cardiology experts rated the severity of thrombotic and bleeding clinical events. The ratings were expressed on a 10-point scale. The median and quartiles of the ratings of each item were returned to the experts. Then, the panel members evaluated the events a second time with knowledge of the group responses from the first round. Cronbach's a was used as a measure of homogeneity for the ratings. The final rating for each event corresponded to the median rating obtained at the last Delphi round.Of 70 experts invited, 32 (46%) accepted to participate. Consensus was reached at the second round as indicated by Cronbach's a value (0.99 (95% CI 0.98-1.00)) so the Delphi was stopped. Severity ranged from under-popliteal venous thrombosis (median = 3, Q1 = 2; Q3 = 3) to ischemic stroke or intracerebral hemorrhage with severe disability at 7 days and massive pulmonary embolism (median = 9, Q1 = 9; Q3 = 9). Ratings did not differ according to the medical specialty of experts.These ratings could be used to weight ischemic and bleeding events of various severity comprising a composite outcome in the field of thrombosis prevention

Autonomous quantum error correction of Gottesman-Kitaev-Preskill states

The Gottesman-Kitaev-Preskill (GKP) code encodes a logical qubit into a bosonic system with resilience against single-photon loss, the predominant error in most bosonic systems. Here we present experimental results demonstrating quantum error correction of GKP states based on reservoir engineering of a superconducting device. Error correction is made autonomous through an unconditional reset of an auxiliary transmon qubit. The lifetime of the logical qubit is shown to be increased from quantum error correction, therefore reaching the point at which more errors are corrected than generated.Comment: 6 pages, 3 figures + 26 pages, 12 figure

Patient and physician factors influence decision-making in hypercholesterolemia: a questionnaire-based survey

Abstract Background Goal attainment of guideline-recommended low-density lipoprotein cholesterol (LDL-C) is suboptimal. Little is known about how patient factors influence physicians’ treatment decision-making in hypercholesterolemia. We examined physicians’ treatment recommendations in high-risk patients whose LDL-C remained uncontrolled despite statin monotherapy. Methods Physicians completed a questionnaire prior to randomization into period I of a two-period randomized controlled trial evaluating LDL-C goal attainment in patients whose LDL-C remained ≥100 mg/dL after 5 weeks’ treatment with atorvastatin 10 mg/day (NCT01154036). Physicians’ treatment recommendations were surveyed for two hypothetical and one real scenario: (1) LDL-C presumed near goal (between 100–105 mg/dL), (2) LDL-C presumed far from goal (~120 mg/dL), and (3) observed baseline LDL-C of enrolled patients. Prognostic factors considered during decision-making were identified by regression analysis. Observed lipid outcomes at the end of period I (following 6 weeks’ treatment with ezetimibe 10 mg plus atorvastatin 10 mg, atorvastatin 20 mg, or rosuvastatin 10 mg) were compared with estimated LDL-C outcomes for physicians’ treatment recommendations after 6 weeks (based on individual patients’ pre-randomization LDL-C and expected incremental change). Results Questionnaires were completed for 1,534 patients. No change in therapy, or double atorvastatin dose, were frequently recommended, even when LDL-C was far from goal (6.5% and 52.2% of patients, respectively). Double atorvastatin dose was commonly recommended in all scenarios (43–52% of patients). More intensive LDL-C-lowering regimens were recommended infrequently e.g. double atorvastatin dose and add ezetimibe only <12% in all scenarios. Overall, cardiovascular risk factors and desire to achieve a more aggressive LDL-C goal were prominent factors in decision-making for treatment. Comparison of observed and estimated LDL-C levels showed that physicians tended to overestimate the effectiveness of their recommendations. Conclusions This study provides insight into physicians’ perspectives on clinical management of hypercholesterolemia and highlights a gap in knowledge translation from guidelines to clinical practice. The need for lower LDL-C and cardiovascular risk were key drivers in clinical decision-making, but physicians’ treatment choices were more conservative than guideline recommendations, potentially resulting in poorer LDL-C reduction. When compared with actual outcomes, projected LDL-C control was better if physicians used more comprehensive strategies rather than simply doubling the statin dose. Trial registration Clinicaltrials.gov: NCT0115403